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SRC seminar 안내. 1월 10일 금요일 오후 6시 Weill Cornell Belfer 1401

January 10 @ 1:00 pm

SRC 연구자 여러분 안녕하세요,

다가오는   2020 1 SRC 세미나 안내입니다.

2020  세미나는 1 10 금요일 오후 6 Weill Cornell Belfer 1401 호에서 진행될 예정이며,

이번 세미나는 NYU Dan R. Littman 실험실에 계신 이준용 박사님께서 “Serum Amyloid A Proteins Induce Pathogenic TH17 Cells and Promote Inflammatory Disease” 주제로 발표를 해주시기로 했습니다.

아시는 분들도 계시겠지만, Dan R. Littman 실험실(https://www.littmanlab.org/) 장내 환경 (Microbiota, metabolite) 어떻게 인체 면역을 조절하는지에 대한 연구를 진행하고 있는 연구실로특히 Th17세포 연구분야를 이끌고 있는 실험실입니다. 2017 여성의 장내미생물이 자폐증 아이의 출산에 직접적인 영향을 미친다는 사실을 규명해서   알려진 하버드대 허준열 교수님도  연구실 출신이십니다.

특히 발표는 이번 12 19 Cell 게재된 최신 연구결과에 대한 발표로, Th17 세포의 분화/활성을 조절하는 인체  면역조절 시스템에 대한 깊이 있는 지식을 얻을  있는 아주 유익한 시간이  것이라 사료됩니다자세한 내용은 아래 초록 또는 아래 링크를 확인하실  있습니다.

https://www.sciencedirect.com/science/article/pii/S0092867419312838?fbclid=IwAR23mrFCBsLlCfjkkWKYVvPS6EfK8K4BQozRjJuNhbQNqBPXg9ZidiDT34s

아무조록 새해를 시작하는  세미나인 만큼 많은 분들께서 참여해주셔서,

유익한 세미나도 듣고좋은 네트워킹도 형성   있는 시간이 되길 바랍니다.

충분한 음식 준비를 위해 아래 링크에RSVP  부탁드립니다.

https://doodle.com/poll/zii5aiqkigaib4bp

 

그럼 2019 한해 마무리 잘하시고,

다가오는 새해에도 하시는 모든일이  되시길 기원하겠습니다.

1 세미나에서 직접 만나뵙도록 하겠습니다.

SRC 회장단 백정은박민주강설희 드림.

Title : Serum Amyloid A Proteins Induce Pathogenic TH17 Cells and Promote Inflammatory Disease

Summary: Lymphoid cells that produce IL-17 cytokines protect barrier tissues from pathogenic microbes, but are also prominent effectors of inflammation and autoimmune disease. T-helper (TH17) cells, defined by RORgt-dependent production of IL-17A and IL-17F, exert homeostatic functions in the gut upon microbiota-directed differentiation from naïve CD4+ T cells. In the non-pathogenic setting, their cytokine production is regulated by serum amyloid A proteins (SAA1 and SAA2) secreted by adjacent intestinal epithelial cells. However, TH17 cell behaviors vary markedly according to their environment. Here we show that SAAs additionally direct a pathogenic pro-inflammatory TH17 cell differentiation program, acting directly on T cells in collaboration with STAT3-activating cytokines. Using loss- and gain-of-function mouse models, we show that SAA1, SAA2, and SAA3 have distinct systemic and local functions in promoting TH17-mediated inflammatory diseases. These studies suggest that T cell signaling pathways modulated by the SAAs may be attractive targets for anti-inflammatory therapies.

Details

Date:
January 10
Time:
1:00 pm
Event Category:
Website:
https://doodle.com/poll/zii5aiqkigaib4bp

Venue

Weill Cornell Belfer
413 E 69th St, New York, NY 10021
New York, NY 10021 United States
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Website:
https://goo.gl/maps/MTXyQdAvzZMCNU1t7