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SRC 9월 온라인 세미나 – 강윤아박사 Columbia

September 24 @ 7:00 pm - 8:00 pm

안녕하세요, SRC 회장단 입니다.

이번 9월부터 SRC 세미나를 온라인 포맷으로 운영하고자 합니다.  

온라인 미팅의 형태로 진행되는 만큼 SRC 계신 분들 뿐만 아니라, 지역의 경계 없이 좋은 연사분들을 초청할 예정이니 많은 관심을 부탁드립니다.

이번에 새롭게 시작하는 9 SRC 온라인  웨비나는 9 24 목요일 저녁 7 진행되며, 콜롬비아에 계시는 강윤아 박사님께서 “Myeloid-biased multipotent progenitor as a new cellular driver of emergency myelopoiesis”  제목으로 발표를 해주실 예정입니다.

 연구는 lineage-biased multipotent progenito emergency myelopoiesis에서 어떤 역할을 하는지어떤 기작이 잘못 조절되면 myeloid leukemia 발생하는지에 대한 발표입니다. 자세한 사항은 초록의 확인을 부탁드리며, 본 세미나에 참석을 원하시는 분들은 아래 링크에서 RSVP를 부탁드립니다.

RSVP: https://docs.google.com/forms/d/e/1FAIpQLSdXaqOTlYetEmP4C8lLnQROgLchQ9wDmYBA7xVmP02lQsFL4Q/viewform

그리고저희가 음식준비에 대한 지출이 없어진 만큼 세미나가 끝나고 경품 추첨 ($50 아마존 상품권  x 1 , $25 아마존 상품권 x 2)  예정이오니  세미나 끝까지 참석하셔서 경품도 받아가시길 바랍니다.

세미나 이후 진행되는 경품추첨은 SRC 소속 연구자 분들만을 대상으로 진행되는 점 양해를 부탁드립니다. 

이번 9 SRC 세미나는 새로운 회장단이 공식적으로 준비하는  번째 세미나이고, 온라인 웨비나라는 새로운 포멧으로 시작하기 때문에 많은 걱정이 있습니다.

바쁘시더라도  시간을 내주셔서 많은 격려와 응원을 부탁드립니다.

그럼 9 세미나에서 직접 만나뵙고 다시 인사드리도록 하겠습니다.

SRC 회장단  강설희이동훈, 백정은 드림.


Abstract

Targeting commonly altered mechanisms in leukemia can provide additional treatment options. Here, we show that an inducible pathway of myeloid regeneration involving the remodeling of the multipotent progenitor (MPP) compartment downstream of hematopoietic stem cells (HSCs) is commonly hijacked in myeloid malignancies. We establish that differential regulation of Notch and Wnt signaling transiently triggers myeloid regeneration from HSCs in response to stress, and that constitutive low Notch and high Wnt activity in leukemic stem cells (LSCs) maintains this pathway activated in malignancies. We also identify compensatory crosstalk mechanisms between Notch and Wnt signaling that prevent damaging HSC function, MPP production, and blood output in conditions of high Notch and low Wnt activity. Finally, we demonstrate that restoring Notch and Wnt deregulated activity in LSCs attenuates disease progression. Our results uncover a mechanism that controls myeloid regeneration and early lineage decisions in HSCs and could be targeted in LSCs to normalize leukemic myeloid cell production.

Details

Date:
September 24
Time:
7:00 pm - 8:00 pm
Event Category:

Venue

New York, NY United States + Google Map